I have 4.10's in my truck. Pulls great, have a little stability issues since mine is a reg. cab short box truck, but that's to be expected.
MPG is horrible, but you're towing so comparing that to others is well...kind of dumb I think.
So far my TPS has been replaced, track bar, front axle u-joints, and the cruise control module. Besides that it has been a great truck.