Pedal bleeding or vacuum bleeding? If pedal bleeding, did you bench bleed the master?
If vacuum bleeding, make sure all connections are not sucking air. This has given myself and a couple others issues in the past. The vacuum will be lost at the bad seal point and may not have enough left to pull fluid out of the cylinder. If this is the case you might wake up tomorrow with a puddle somewhere after gravity has a bit more time to work its magic.
Port location shouldn't affect the ability to bleed the system but may change the overall performance if all 4 corners are pulling from the same piston travel section. Assuming you are using 1 forward and 1 rearward port and block the others you should be fine.
If you can read this, thank a teacher. If you can read it while pooping, thank Bill Gates!
"A girls butt hole is like a 9 volt battery. You know its wrong, but eventually you put your tongue on it."