They lived in a household with a Yorkshire Terrier for a year during my last deployment, so they have had some exposure to dogs. The male will just run/hide. The female dealt with the dog better and would probably adapt just fine after a while. In the case of a large dog, it would probably depend on how much the dog messed with them. As long as they had a retreat point like the cat tree or something, it would probably be fine since they still have claws.
They are not from the same litter. I had the female by herself for about three years. They are not clingy to each other.
They are both currently boarded at Serenity again.