Don't quote me on this but i do not see why it would hurt anything. It does not hurt anything in a truck with a solid axle and the TTB front end still has similar components to a solid axle. It is still just axle shafts and a differential with a different design.
You will cause extra wear on your front end and probably see a very minuscule drop in gas mileage but that should be all. I always use to keep mine locked in the winter unless i was going on a long highway haul.