am not a gun expert therefore this is definately an opinion
if it's for home defense and you think you can get to it before the intruders get to you, go for a 'special purpose' shot gun. don't think these's anything scarier than hearing someone rack a shell in another part of the house.
check with local law enforcement (and let me know) about your liability when protecting yourself by blowing 00buckshot through a wall when you cannot see the intruder(s) but you know they're present. 00 is gonna give you a better first-strike capability.