Jeremy, if you plan on doing pocket porting on the heads yourself, invest in some porting templates from Mopar. For my airflow project last semester, me and a buddy used those on his 360 heads and had an increase of about 45 cfm, and we didn't hit any water jackets.
If you're looking at aftermarket heads and cams and stuff, pay attention to where you're going to be shifting your powerband. If you start building that thing up to make max power, it's all going to be high up in the RPM range, where you don't necessariliy want it. Build for mid-range, and the lower end and higher end will increase along with it, but you'll keep your peak where you want it.
Bigger isn't always better, don't go making everything bigger. It'll kill your lower end. For lower end torque and mid-range power, you want things to be a little smaller. You want velocity through the intake and exhaust to be high, and big ass headers, ports and an intake kill velocity at lower RPMs.